The use of rhBMP2 for augmentation of established horizontal/vertical defects may require additional use of rhVEGF to achieve significant bone regeneration: An in vivo experimental study

Aim To test the hypothesis that use of rhBMP2 in established defects requires additional growth factors such as rhVEGF to accomplish effective bone repair. Materials and Methods Horizontal/vertical 2 cm length 1 height were created bilaterally alveolar crest maxillae 18 minipigs together with extraction all premolar teeth one molar tooth on both sides. After 3 months healing, augmented 0.5 g particulate PDLLA/CaCO3 composite loaded 400 µg rhBMP2/50 rhVEGF165 side 800 other 12 animals, whereas six control animals sham operated left unfilled blank carriers other. 4 13 weeks, evaluated each for area new formation (mm²) density (area %). Results Augmentations µrhBMP2 failed induce significantly more than augmentations unloaded carrier after weeks (p = .1000, p .381). 50 erhVEGF165 resulted increased .024) compared carriers. Soft tissue combined rhBMP2/rhVEGF165 loading exhibited numerous microvessels soft rhBMP2. Conclusions It is concluded regeneration ridge may require application additionally